Change or disable the Front Row shortcut
This isn't very well publicised, and the only reason I know about it is that I keep accidentally pressing it when I go to Force Quit an application (Command-Option-Escape). People with American keyboard layouts also report accidentally activating Front Row when going for Command-Tilde (cycle through windows). As Front Row often takes a few seconds to load up and it takes over your entire screen, this can be pretty annoying.
If you are as clumsy as me, you might want to change the keyboard shortcut for Front Row. This is easily done by going to the Keyboard and Mouse section of System Preferences. Under the Keyboard Shortcuts tab you should find a list of all the keyboard shortcuts you can change.
Simply double-click on the shortcut for "Hide and show Front Row" and press the new combination you want. I went for Command-Control-Escape, as it's almost the same but much harder to accidentally press.
Alternatively, if you want to disable the shortcut completely, just un-check the box to the left of "Hide and show Front Row". Even if you do this, Front Row is still accessible via the remote.